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Research

Ann Marie Schmidt, MD photo
Ann Marie Schmidt, M.D.
Division Chief

The Division of Surgical Science at Columbia University's Department of Surgery was established in 2000 to advance and innovate the field of medicine—and improve the specialty of surgery—through scientific inquiry and research cooperation. In the four years of our existence, our unique group of physician-scientists has worked on a number of important research collaborations with both internal and external colleagues, seeking fundamental insights into a wide range of diseases and conditions. Examples include:

  • Cardiovascular disease
  • Diabetes: its etiology & complications
  • Autoimmune disorders, such as multiple sclerosis and the complications of allotransplanation
  • Alzheimer's disease, Amyotrophic lateral sclerosis & other neurodegenerative diseases
  • Cancer

We are proud to announce that Dr. Shi-Fang Yan was recently awarded an RO1 grant from the National Institutes of Health (NIH) to study the mechanisms linking Early Growth Response-1 and atherosclerosis. In addition, we are currently collaborating with the Division of Abdominal Organ Transplantation on research studies that explore the limits of liver regeneration. Initial findings from our efforts, which focus on the blockage of RAGE, were published in the February 7, 2005 issue of The Journal of Experimental Medicine. To learn more about those findings, please click here.

2004 was an especially exciting and momentous year for the Division of Surgical Science. For the second time in the division's short history, we were designated an official Juvenile Diabetes Research Foundation (JDRF) Center for Diabetes Complications. With our grant from the JDRF—and a new partnership with world-renowned researchers from the Naomi Berrie Diabetes Center—we will be able to move even beyond the complications of diabetes, harnessing the power of basic and clinical research to optimize islet cell transplants for type-1 diabetes patients.

We also are pleased to announce that, in 2004, we were awarded competitive renewal of our Program Project award from the NIH's National Lung, Heart, and Blood Institute. The continuation of this grant will allow us to build upon our previous studies of cardiovascular disease and RAGE, a molecule implicated in a whole host of illnesses (including multiple sclerosis, diabetes, rheumatoid arthritis, and more).

And we remain the recipients of an Alzheimer's disease award from the National Institutes of Aging to study the basic science and molecular mechanisms underlying the progression of AD.

We are proud to say that our division is home to some of the country's most cutting-edge research initiatives—ones that have the potential, promise, and power to alleviate major sources of human suffering. Please feel free to click through our pages for more details and information on specific research projects sponsored by the division. We hope you find our work as fascinating as we do.

Ann Marie Schmidt, M.D.
Division Chief, Surgical Science
Director, JDRF Center for Diabetes Complications

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